反応 #1833265

反応方程式

(trans)-2-phenylcyclopropanamine

intermediate A

(trans)-2-phenylcyclopropanamine

K2CO3

→

tert-butyl(trans)-2-phenylcyclopropylcarbamate

収率 189.3%

溶媒

THF

反応条件

後処理

1. 1
   その他After removal of the solvent, CH2Cl2
2. 2
   workup.ADDITIONwas added
3. 3
   洗浄washed with a saturated solution of NaHCO3 and brine
4. 4
   抽出The organic layer was extracted
5. 5
   乾燥dried with MgSO4
6. 6
   ろ過filtered
7. 7
   その他The crude was purified by silica gel chromatography (Hexane-MTBE 90:10)

実験手順

Over a solution of (trans)-2-phenylcyclopropanamine (intermediate A, 1.14 g, 1 eq) in 50 mL of THF, 1.25 g (1.05 eq) of K2CO3 was added and stirred 3 hours at room temperature. After removal of the solvent, CH2Cl2 was added, then washed with a saturated solution of NaHCO3 and brine. The organic layer was extracted, dried with MgSO4 and filtered. The crude was purified by silica gel chromatography (Hexane-MTBE 90:10) affording 1.89 g of tert-butyl(trans)-2-phenylcyclopropylcarbamate. Yield: 95%

出典