反応 #1833242

反応方程式

3-Bromo-6-fluoro-2-hydroxybenzaldehyde

NaHSO3

hydrogen peroxide

→

3-Bromo-6-fluorobenzene-1,2-diol

溶媒

NaOH

water

反応条件

後処理

1. 1
   温度External cooling
2. 2
   その他controlled below 50° C
3. 3
   抽出extracted with ethyl acetate (2×75 mL)
4. 4
   洗浄The combined extracts were washed with saturated NaCl (20 mL)
5. 5
   乾燥dried (Na2SO4)
6. 6
   その他evaporated
7. 7
   その他The catechol derivative, as a dark orange liquid, was carried to the next step without further purification (8.9 g, qt)

実験手順

3-Bromo-6-fluoro-2-hydroxybenzaldehyde (9.0 g, 41 mmol, prepared according to Castro, Alfred C.; Depew, Kristopher M.; Grogan, Michael J.; Holson, Edward B.; Hopkins, Brian T.; Johannes, Charles W.; Keaney, Gregg F.; Koney, Nii O.; Liu, Tao; Mann, David A.; Nevalainen, Marta; Peluso, Stephane; Perez, Lawrence Blas; Snyder, Daniel A.; Tibbitts, Thomas T., WO 2008024337 A2) was stirred in 1.0 M NaOH (47 mL) and treated with hydrogen peroxide (6%; 49 g, 86 mmol). External cooling was applied to keep the temperature controlled below 50° C. After 2 h total stirring, the mixture was stirred with a solution of NaHSO3 in 50 mL water and extracted with ethyl acetate (2×75 mL). The combined extracts were washed with saturated NaCl (20 mL), dried (Na2SO4) and evaporated. The catechol derivative, as a dark orange liquid, was carried to the next step without further purification (8.9 g, qt): EIMS m/z 206.

出典