反応 #1832011

反応方程式

product

4-{5-[2-(4-benzo[d]isothiazol-3-yl-piperazin-1-yl)ethyl]-6-chloro-2-oxo-2,3-dihydro-indol-1-yl}-4-oxo-butyric acid methyl ester, hydrochloride salt

ethanol

hydrochloric acid

→

4-{5-[2-(4-benzo[d]isothiazol-3-yl-piperazin-1-yl)ethyl]-6-chloro-2-oxo-2,3-dihydro-indol-1-yl}-4-oxo-butyric acid ethyl ester, hydrochloride salt

溶媒

water

反応条件

後処理

1. 1
   温度under reflux for 24 h in the temperature
2. 2
   その他range 78-80° C
3. 3
   その他removed during the hot filtration
4. 4
   温度The filtrate was cooled further
5. 5
   その他product solids were isolated by filtration
6. 6
   洗浄washed with distilled water (20 mL)
7. 7
   その他dried under vacuum
8. 8
   その他to yield 200 mg (32%)

実験手順

The product of Example 5, (611 mg, 1.1 mmol) was mixed with ethanol (27 mL) and concentrated hydrochloric acid (0.5 mL) and the mixture boiled under reflux for 24 h in the temperature range 78-80° C. Distilled water (20 mL) was added to the hot reaction mixture and solids removed during the hot filtration. The filtrate was cooled further and product solids were isolated by filtration, washed with distilled water (20 mL), and dried under vacuum to yield 200 mg (32%).

出典