反応 #1824320

反応方程式

2,5-dithia cyclohexanone

cysteine decyl ester hydrochloride

triethyl amine

→

S-(2-mercaptoethyl)-N-(2-mercapto-1(decyloxycarbonyl)-ethyl)-mercaptoacetamide

溶媒

dichloromethane

dichloromethane

反応条件

後処理

1. 1
   workup.ADDITIONare added
2. 2
   洗浄washed three times with 2% aqueous citric acid, saturated sodium hydrogencarbonate solution
3. 3
   乾燥After drying above sodium sulfate
4. 4
   その他the solvent is evaporated under reduced pressure
5. 5
   その他The oily residue is crystallized by trituration with diethyl ether

実験手順

13.42 g (0.1 mol) of 2,5-dithia cyclohexanone dissolved in 250 ml of anhydrous dichloromethane are added by dropping, and in an argon atmosphere, to a solution of 29.79 g (0.1 mol) of cysteine decyl ester hydrochloride and 10.12 g (0.1 mol) of triethyl amine in 500 ml of anhydrous dichloromethane. The reaction mixture is kept agitated overnight at room temperature and then washed three times with 2% aqueous citric acid, saturated sodium hydrogencarbonate solution and with water. After drying above sodium sulfate, the solvent is evaporated under reduced pressure. The oily residue is crystallized by trituration with diethyl ether.

出典