反応 #1823

ord-19ef8b5233de4220a1842b9d3ce2334f

反応方程式

OC[C@H]1O[C@@H](O[C@@H]2[C@@H](CO)O[C@](O)(CO)[C@H]2O)[C@H](O)[C@@H](O)[C@H]1O
lactitol
OC[C@H]1O[C@@H](O[C@@H]2[C@@H](CO)O[C@](O)(CO)[C@H]2O)[C@H](O)[C@@H](O)[C@H]1O
lactitol
O.O.OC[C@@H](O)[C@@H](O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O)[C@H](O)[C@@H](O)CO
lactitol dihydrate
→
O.OC[C@@H](O)[C@@H](O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O)[C@H](O)[C@@H](O)CO
lactitol monohydrate
収率 4.9%

反応物

OC[C@H]1O[C@@H](O[C@@H]2[C@@H](CO)O[C@](O)(CO)[C@H]2O)[C@H](O)[C@@H](O)[C@H]1O
lactitol
OC[C@H]1O[C@@H](O[C@@H]2[C@@H](CO)O[C@](O)(CO)[C@H]2O)[C@H](O)[C@@H](O)[C@H]1O
lactitol
O.O.OC[C@@H](O)[C@@H](O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O)[C@H](O)[C@@H](O)CO
lactitol dihydrate
—
dihydrate

試薬

なし

溶媒

O
water

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    workup.DISSOLUTIONdissolves)
  2. 2
    その他After crystallization for 48 hours at 45° C. the crystals
  3. 3
    その他formed
  4. 4
    その他were separated from the mother liqouor in a laboratory centrifuge
  5. 5
    洗浄washed with 25 ml water
  6. 6
    その他dried at 45° C.
  7. 7
    その他(drying cabinet)

実験手順

950 g lactitol dihydrate (860 g anhydric lactitol) were dissolved in 125 g water at 100° C. Upon cooling to 50° C. the 80 percent by weight lactitol solution was seeded with 9.5 g ground dihydrate (1 percent by weight based on the lactitol dissolves). After crystallization for 48 hours at 45° C. the crystals formed were separated from the mother liqouor in a laboratory centrifuge, washed with 25 ml water and dried at 45° C. (drying cabinet). There were then obtained 440 g lactitol monohydrate (melting point: 118°-120° C.; moisture content: 4.9%) or 49% based on the lactitol used.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US05726303uspto-grants-1998_03