反応 #1820955

反応方程式

N-Boc-O-benzylserine hydroxysuccinimide

→

N-Boc-O-benzylserine methyl ester

溶媒

methanol

反応条件

後処理

1. 1
   その他The solvent was evaporated
2. 2
   洗浄washed with aqueous saturated sodium bicarbonate (2×50 ml) and water (50 ml)
3. 3
   乾燥The organic solution was dried with sodium sulphate
4. 4
   その他after evaporation of the solvent the N-Boc-O-benzylserine methyl ester
5. 5
   その他was isolated as a colourless oil

実験手順

N-Boc-O-benzylserine-hydroxysuccinimide (16.0 g, 40.8 mmol) was dissolved in methanol (300 ml) and stirred at 50° C. for 24 hours. The solvent was evaporated and the residue was taken up in ethyl acetate (120 ml), washed with aqueous saturated sodium bicarbonate (2×50 ml) and water (50 ml). The organic solution was dried with sodium sulphate and after evaporation of the solvent the N-Boc-O-benzylserine methyl ester was isolated as a colourless oil. Yield 9.9 g (83%). The structure was confirmed by 1HNMR and 13CNMR.

出典