反応 #1820503

反応方程式

1-methyl-4-(α-phenyl-2-tolyl)-4-piperidinol

benzoyl chloride

→

4-benzoyloxy-1-methyl-4(α-phenyl-2-tolyl)piperidine hydrochloride

溶媒

ether

反応条件

後処理

1. 1
   温度cooling
2. 2
   workup.STIRRINGstirred for two hours
3. 3
   ろ過the resulting precipitate collected by suction filtration
4. 4
   洗浄The filter cake is washed well with ether
5. 5
   乾燥dried in vacuo at 40° C. over sodium hydroxide pellets
6. 6
   ろ過The dried filter cake
7. 7
   その他is recrystallized twice from a chloroform-ether mixture

実験手順

2.0 g of 1-methyl-4-(α-phenyl-2-tolyl)-4-piperidinol, Example 1, is treated with 10 ml of benzoyl chloride with stirring and cooling. The reaction solution is diluted with 20 ml of ether, stirred for two hours and the resulting precipitate collected by suction filtration. The filter cake is washed well with ether and dried in vacuo at 40° C. over sodium hydroxide pellets. The dried filter cake is recrystallized twice from a chloroform-ether mixture to give colorless crystals, mp 197°-198° C. of 4-benzoyloxy-1-methyl-4(α-phenyl-2-tolyl)piperidine hydrochloride.

出典