反応 #1818772

反応方程式

isopropanol

BOC-Arg

HCl

MeOH

→

H-Arg

収率 163.0%

溶媒

HCl AcOH

反応条件

後処理

1. 1
   その他reprecipitated in AcOEt
2. 2
   その他The crystals precipitated
3. 3
   ろ過were collected by filtration
4. 4
   その他dried

実験手順

243.7 Grams (0.55 mol) of BOC-Arg-CHA.HCl was dissolved in 1,093 ml of 2N-HCl/AcOH and a small quantity of MeOH, and the mixture was reacted at room temperature for 1 hour. After the reaction was completed, to the reaction mixture was added with 1,093 ml of isopropanol and reprecipitated in AcOEt. The crystals precipitated were collected by filtration and dried to obtain 156.2 g (74.3%) of H-Arg-CHA.2HCl. Rf3 =0.15. Melting point: 240.5° C. (decomposed). [α]D20 +53.5 (C=1, H2O)

出典