反応 #1818738

反応方程式

hexahydro-4,7-methano-iso-benzofuran-1(3H)-one

methanol

→

1-hydroxyoctahydro-4,7-methano-iso-benzofuran

収率 98.0%

溶媒

toluene

toluene

sodium chloride

反応条件

後処理

1. 1
   その他to run in at -70° to -78° C
2. 2
   workup.STIRRINGthe mixture is subsequently stirred at 20° C. for 15 minutes
3. 3
   その他The organic phase is separated off
4. 4
   抽出the aqueous phase is extracted with ethyl acetate
5. 5
   洗浄washed with saturated aqueous sodium chloride solution
6. 6
   乾燥dried over sodium sulphate
7. 7
   その他the solvent is evaporated off in vacuo

実験手順

30.4 g (0.2 mole) of hexahydro-4,7-methano-iso-benzofuran-1(3H)-one are introduced into 800 ml of absolute toluene, under an inert gas, and 84.8 ml (0.3 mole) of sodium bis-(2-methoxy-ethoxy)-dihydridoaluminate (70% strength solution in toluene), diluted with 200 ml of absolute toluene, are allowed to run in at -70° to -78° C. The mixture is stirred at -70° to -78° C. for 6 hours. Thereafter, 580 ml of 50% strength aqueous methanol are added dropwise at -70° C. and the mixture is subsequently stirred at 20° C. for 15 minutes and diluted with 400 ml of saturated aqueous sodium chloride solution. The organic phase is separated off and the aqueous phase is extracted with ethyl acetate. The organic phases are combined, washed with saturated aqueous sodium chloride solution and dried over sodium sulphate and the solvent is evaporated off in vacuo. 30.1 g (98% yield) of 1-hydroxyoctahydro-4,7-methano-iso-benzofuran are obtained in this manner.

出典