反応 #1810805

ord-941be3564bea4ff8bf63eedef6b4b1ab

反応方程式

CC(C)(C)OC(=O)N[C@H]1CC[C@H](NC(N)=S)CC1
(trans-4-thioureido-cyclohexyl)-carbamic acid tert-butyl ester
CI
methyliodide
→
CSC(=N)N[C@H]1CC[C@H](NC(=O)OC(C)(C)C)CC1
[trans-4-(2-methyl-isothioureido)-cyclohexyl]-carbamic acid tert-butyl ester

反応物

CC(C)(C)OC(=O)N[C@H]1CC[C@H](NC(N)=S)CC1
(trans-4-thioureido-cyclohexyl)-carbamic acid tert-butyl ester
CI
methyliodide

試薬

なし

溶媒

CO
MeOH

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    その他From the mixture obtained solvent
  2. 2
    その他is evaporated

実験手順

A mixture of 1.19 g of (trans-4-thioureido-cyclohexyl)-carbamic acid tert-butyl ester and 0.41 ml of methyliodide in 50 ml of MeOH is stirred at RT. From the mixture obtained solvent is evaporated and [trans-4-(2-methyl-isothioureido)-cyclohexyl]-carbamic acid tert-butyl ester in the form of a hydrolodide is obtained.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US07485632B2uspto-grants-2009_02