反応 #1810804

ord-6b9eff78a38a418fb8f6b9ea9abca057

反応方程式

[Na+].[OH-]
NaOH
CCOC(=O)NC(=S)N[C@H]1CC[C@H](NC(=O)OC(C)(C)C)CC1
[trans-4-(3-ethoxycarbonyl-thioureido)cyclohexyl]carbamic acid tert-butyl ester
→
CC(C)(C)OC(=O)N[C@H]1CC[C@H](NC(N)=S)CC1
(trans-4-Thioureido-cyclohexyl)-carbamic acid tert-butyl ester

反応物

[Na+].[OH-]
NaOH
CCOC(=O)NC(=S)N[C@H]1CC[C@H](NC(=O)OC(C)(C)C)CC1
[trans-4-(3-ethoxycarbonyl-thioureido)cyclohexyl]carbamic acid tert-butyl ester

試薬

なし

溶媒

O
H2O
CCO
EtOH

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    その他The mixture obtained
  2. 2
    その他The precipitate formed
  3. 3
    ろ過is filtered
  4. 4
    洗浄washed with diethylether

実験手順

7.4 ml of 4M NaOH are added to a suspension of 1.69 g of [trans-4-(3-ethoxycarbonyl-thioureido)cyclohexyl]carbamic acid tert-butyl ester in 10 ml of H2O and 15 ml of EtOH. The mixture obtained is kept at 90° for 30 minutes at RT. The precipitate formed is filtered and washed with diethylether. (trans-4-Thioureido-cyclohexyl)-carbamic acid tert-butyl ester is obtained.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US07485632B2uspto-grants-2009_02