反応 #1810790

反応方程式

hydrochloric acid

methyl 2-hydroxy-3,3,3-trifluoro-2-trifluoromethylpropionate

sodium boron hydride

water

→

3,3,3-trifluoro-2-trifluoromethyl-1,2-propane diol

収率 96.0%

溶媒

diethyl ether

反応条件

後処理

1. 1
   workup.STIRRINGStirring
2. 2
   その他to quench
3. 3
   その他the reaction
4. 4
   その他The organic layer was separated
5. 5
   濃縮concentrated
6. 6
   workup.DISTILLATIONdistilled

実験手順

With stirring, 100 g of methyl 2-hydroxy-3,3,3-trifluoro-2-trifluoromethylpropionate was added dropwise to a mixture of 25.0 g sodium boron hydride, 500 g water and 500 g diethyl ether. Stirring continued for 10 hours, after which hydrochloric acid was added to quench the reaction. The organic layer was separated, concentrated, and distilled, obtaining 83.9 g of 3,3,3-trifluoro-2-trifluoromethyl-1,2-propane diol (yield 96%).

出典