反応 #1810685

反応方程式

( A )

(E)-2-[2-(3-chloropropoxyphenyl)ethenyl]benzoxazole

N-methylpiperazine

→

title compound

(E)-2-[2-[3-[3-(4-Methylpiperazino)propoxy]phenyl]ethenyl]benzoxazole

反応条件

後処理

1. 1
   その他The title compound was prepared

実験手順

The title compound was prepared as described in Example 1 starting with (A) of Example 1 (2.0 g, 6.4 mmol) and using N-methylpiperazine in place of dibutylamine to produce 0.56 g (25% yield of the free base of the title compound which was converted to the HCl salt, mp 250°-252° C. IR: 1600 cm-1. MS: 378(MH+). 1H NMR (CDCl3): δ 7.82-7.00 (m, 10H), 4.13 (t, J=5.2 Hz, 2H), 3.31 (m, 13H), 2.41 (m, 2H).

出典