反応 #1797517

反応方程式

1-(4-tert-butylphenyl)-3-(4-(hydroxymethyl)phenyl)imidazolidin-2-one

4-methylmorpholine N-oxide

tetrapropylammonium

→

4-(3-(4-tert-Butylphenyl)-2-oxoimidazolidin-1-yl)benzaldehyde

溶媒

acetonitrile

反応条件

後処理

1. 1
   ろ過The solids were filtered
2. 2
   濃縮the filtrated was concentrated
3. 3
   その他The residue was purified on ISCO system (2% methanol in dichloromethane)
4. 4
   その他to give a pure product as a white crystalline (72 mg, 73%)

実験手順

A mixture of 1-(4-tert-butylphenyl)-3-(4-(hydroxymethyl)phenyl)imidazolidin-2-one (100 mg, 0.31 mmol), 4-methylmorpholine N-oxide (72 mg, 0.62 mmol), and 4 A molecular sieves (100 mg) in 10 ml of acetonitrile was treated with tetrapropylammonium perruthnate and the resulting mixture was stirred at room temperature for 3 hours. The solids were filtered and the filtrated was concentrated. The residue was purified on ISCO system (2% methanol in dichloromethane) to give a pure product as a white crystalline (72 mg, 73%): 1H NMR (400 MHz, CDCl3) δ 9.93 (s, 1H), 7.81 (d, 2H), 7.79 (d, 2H), 7.50 (d, 2H), 7.40 (d, 2H), 4.03 (s, 4H), 1.33 (s, 9H). MS (ESI) m/z: Calculated: 322.17; Observed: 323.1 (M++1).

出典