反応 #1797511

反応方程式

6-(5-chloro-2-hydroxyphenyl)-pyridine-2-carboxylic acid

nitric acid

→

6-(5-chloro-2-hydroxy-3-nitrophenyl)-pyridine-2-carboxylic Acid

溶媒

water

acetic acid

反応条件

後処理

1. 1
   workup.ADDITIONwas added 1 ml
2. 2
   その他The resulting precipitation
3. 3
   その他was collected
4. 4
   洗浄washed
5. 5
   その他dried
6. 6
   その他to give solid (2.74 g; 78%, three steps)

実験手順

To the solution of 6-(5-chloro-2-hydroxyphenyl)-pyridine-2-carboxylic acid; (2.3 g, 10.1 mmol) in 100 ml acetic acid; was added 1 ml fuming nitric acid; and stirred at 35° C. to 40° C. for half an hour. The reaction mixture was diluted with water and adjusted pH to 2.5. The resulting precipitation was collected, washed and dried to give solid (2.74 g; 78%, three steps). MS (ES) m/z 295 [M+H].

出典