反応 #1797505

反応方程式

sodium methoxide

6-Methoxy-6-methyl-2-octanone

tert.-butyl methyl ether

methyl chloroacetate

→

3-(4-methoxy-4-methyl-hexyl)-3-methyl-oxirane-2-carboxylic acid methyl ester

収率 67.5%

溶媒

acetic acid

反応条件

後処理

1. 1
   その他the phases were separated
2. 2
   抽出The aqueous phase was extracted with tert.-butyl methyl ether (500 ml)
3. 3
   洗浄The combined organic phases were washed with water, concentrated KHCO3 solution, concentrated NaCl solution
4. 4
   乾燥dried over MgSO4
5. 5
   その他after the removal of the solvent
6. 6
   workup.DISTILLATIONwas distilled over a small Vigreux-column

実験手順

860 g 6-Methoxy-6-methyl-2-octanone, 4 l tert.-butyl methyl ether and 648 g methyl chloroacetate were cooled to 0° C. under a blanket of nitrogen. Under further cooling, 350 g sodium methoxide was added in 6 portions over 20 minutes. The mixture was then stirred at room temperature till no more consumption of the ketone was observed (GC). After cooling to 0° C., 1 l 5% acetic acid (w/w) was added and the phases were separated. The aqueous phase was extracted with tert.-butyl methyl ether (500 ml). The combined organic phases were washed with water, concentrated KHCO3 solution, concentrated NaCl solution and dried over MgSO4. The yellow oil which remained after the removal of the solvent was distilled over a small Vigreux-column to give 823 g of 3-(4-methoxy-4-methyl-hexyl)-3-methyl-oxirane-2-carboxylic acid methyl ester (mixture of isomers, boiling point: 115°-128°/0.3 Torr=0.399 mbar).

出典