反応 #1797474

反応方程式

PCC

6-benzyloxy-1-hexanol

→

6-benzyloxy-1-hexanal

溶媒

methylene chloride

反応条件

後処理

1. 1
   ろ過filtered through 50 g of silica gel
2. 2
   その他The solvent was removed
3. 3
   その他the crude oil was separated chromatographically on silica gel using
4. 4
   workup.ADDITIONa mixture of hexane

実験手順

Synthesis of [18F]-FCPHA was performed using the following method. PCC (pyridinium chlorochromate; 24.8 g, 115.2 mmol) was slowly added in portions to a solution of 6-benzyloxy-1-hexanol (20 g, 96 mmol) in 200 ml of methylene chloride at room temperature (25° C., RT). The black mixture was stirred for 2 hours, and filtered through 50 g of silica gel. The solvent was removed and the crude oil was separated chromatographically on silica gel using a mixture of hexane:ethyl acetate at a ratio of 90:10. This yielded the aldehyde equivalent, 6-benzyloxy-1-hexanal, at a scale of 14 g (70%).

出典