反応 #1792

反応方程式

sulfonylpyran-4-one

NaBH4

→

sulfonylpyran-4-ol

溶媒

MeOH

反応条件

後処理

1. 1
   その他The solvent was removed under reduced pressure
2. 2
   その他the crude oil was chromatographed on a silica gel column
3. 3
   洗浄hexanes and eluted with same
4. 4
   その他the solvent was removed under reduced pressure

実験手順

A stirred solution of sulfonylpyran-4-one (1.2 g, 8.1 mmol) in MeOH (20 mL) was cooled to 0° C. under Argon and treated with NaBH4 (331 mg, 9.0 mmol). The reaction was stirred over 16 h and allowed to warm to ambient temperature. The solvent was removed under reduced pressure and the crude oil was chromatographed on a silica gel column packed in 50:50 EtOAc:hexanes and eluted with same. The appropriate fractions were combined and the solvent was removed under reduced pressure to give the sulfonylpyran-4-ol.

出典