反応 #1791507

反応方程式

7-(4-chlorobenzoyl)-3-methylthioindolin-2-one

→

7-(4-Chlorobenzoyl)indolin-2-one

収率 93.0%

溶媒

tetrahydrofuran

反応条件

後処理

1. 1
   workup.ADDITIONAfter the addition
2. 2
   ろ過was filtered
3. 3
   workup.ADDITIONA drop of concentrated hydrochloric acid was added to the filtrate which
4. 4
   その他removed some color
5. 5
   その他to yield a cream color material
6. 6
   その他Recrystallization from toluene
7. 7
   その他gave needles, (93% yield)
8. 8
   その他sintered at 177° C.

実験手順

A stirred solution of 9 g. (0.028 mole) of 7-(4-chlorobenzoyl)-3-methylthioindolin-2-one in 180 ml. of tetrahydrofuran was treated over a two-hour period with 45 g. of a commercial Raney nickel water suspension. After the addition was complete the mixture was filtered. A drop of concentrated hydrochloric acid was added to the filtrate which removed some color and the resulting solution was then stripped under water pump vacuum to yield a cream color material. Recrystallization from toluene gave needles, (93% yield); the material sintered at 177° C. and melted at 186° C.

出典