反応 #1791

反応方程式

methyl 4-[N-Boc-cis-1-amino-4-cyclohexanoyloxy]-2-methoxybenzoate

H2O

LiOH.H2O

→

4-[N-Boc-cis-1-amino-4-cyclohexanoyloxy]-2-methoxybenzoic acid

溶媒

THF

反応条件

後処理

1. 1
   温度cooled to ambient temperature
2. 2
   その他The solvent was removed under reduced pressure
3. 3
   洗浄CH2Cl2 and eluted with same
4. 4
   その他The solvent was removed under reduced pressure

実験手順

To a stirred solution of methyl 4-[N-Boc-cis-1-amino-4-cyclohexanoyloxy]-2-methoxybenzoate (220 mg, 0.52 mmol) in THF:H2O (5 mL: 1 mL) was added LiOH.H2O (67.6 mg, 1.59 mmol). The reaction was heated to 45° C. over 12 h and then cooled to ambient temperature. The solvent was removed under reduced pressure. The crude solid passed through a plug of silca gel packed in 50:50 MeOH:CH2Cl2 and eluted with same. The solvent was removed under reduced pressure to afford 4-[N-Boc-cis-1-amino-4-cyclohexanoyloxy]-2-methoxybenzoic acid as a white solid.

出典