反応 #1788

反応方程式

2,4-dimethyl-3-hydroxymethylpyridine

thionyl chloride

→

2,4-dimethyl-3-chloromethylpyridine

溶媒

CH2Cl2

反応条件

後処理

1. 1
   その他The solvent was removed under reduced pressure
2. 2
   その他the residue was partitioned between CH2Cl2 and saturated aqueous sodium bicarbonate
3. 3
   乾燥The organic layer was dried with MgSO4
4. 4
   ろ過filtered
5. 5
   その他the solvent removed under reduced pressure

実験手順

The 2,4-dimethyl-3-hydroxymethylpyridine (19.2 g, 140 mmol) was dissolved in CH2Cl2 (800 mL) and cooled under nitrogen to 0° C. and thionyl chloride (125 mL) was slowly added and the reaction was stirred for 18 hours. The solvent was removed under reduced pressure and the residue was partitioned between CH2Cl2 and saturated aqueous sodium bicarbonate. The organic layer was dried with MgSO4, filtered and the solvent removed under reduced pressure to give the desired 2,4-dimethyl-3-chloromethylpyridine.

出典