反応 #1787789

反応方程式

hydrochloric acid

7-(2-chlorophenyl)-4-methyl-5,6,7,8-tetrahydroquinazolin-5-one

aminoguanidine hydrochloride

→

(E)-7-(2-chlorophenyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinazoline hydrochloride

収率 141.9%

溶媒

ethanol

反応条件

後処理

1. 1
   温度cooled
2. 2
   濃縮The reaction solution was concentrated under reduced pressure
3. 3
   洗浄the residue was washed with ethanol, ethyl acetate and isopropylether
4. 4
   その他dried

実験手順

To a mixture of 7-(2-chlorophenyl)-4-methyl-5,6,7,8-tetrahydroquinazolin-5-one (40 mg) and aminoguanidine hydrochloride (16 mg) were added ethanol (3 ml) and 6N hydrochloric acid (0.025 ml), and the mixture was stirred at 90° C. for 3 hours and cooled. The reaction solution was concentrated under reduced pressure, and the residue was washed with ethanol, ethyl acetate and isopropylether, and dried to give (E)-7-(2-chlorophenyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinazoline hydrochloride (Compound 89) (38 mg).

出典