反応 #1785955

反応方程式

(R)-(−)-2-[3-[3-(1 -tert-butylcarbonylmethyl-2-oxo-5-cyclohexyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-3-yl)ureido]phenyl]-2-methylpropionic acid

sodium hydroxide

→

title compound

sodium (R)-2-[3-[3-(1-tert-butylcarbonylmethyl-2-oxo-5-cyclohexyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-3-yl)ureido]phenyl]-2-methylpropionate

溶媒

methanol

反応条件

後処理

1. 1
   濃縮The solution was concentrated under reduced pressure
2. 2
   その他The residue was purified through HP-20 (“Diaion”, product of Mitsubishi Chemical Corporation) by means of water and methanol

実験手順

To a solution of (R)-(−)-2-[3-[3-(1 -tert-butylcarbonylmethyl-2-oxo-5-cyclohexyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-3-yl)ureido]phenyl]-2-methylpropionic acid (960 mg) in methanol (10 mL), 1 N sodium hydroxide (1.79 mL) was added. The solution was concentrated under reduced pressure. The residue was purified through HP-20 (“Diaion”, product of Mitsubishi Chemical Corporation) by means of water and methanol. The thus-purified residue was lyophilized, whereby the title compound (900 mg) was obtained.

出典