反応 #1785954

反応方程式

(R)-(−)-2-[3-[3-(1-tert-Butylcarbonylmethyl-2-oxo-5-c yclohexyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-3-yl)urei do]phenyl]-2-methylpropionic acid

N,N′-dibenzylethylenediamine

→

title compound

収率 89.3%

(R)-2-[3-[3-(1-tert-butylcarbonylmethyl-2-oxo-5-cyclohexyl-1,3,4,5-tetrahydro-2H-1,5-benzodi azepin-3-yl)ureido]phenyl]-2-methylpropionic acid N,N′-dibenzylethylenediamine salt

収率 89.3%

溶媒

acetonitrile

反応条件

後処理

1. 1
   workup.DISSOLUTIONwere then dissolved
2. 2
   温度under heat
3. 3
   その他Crystals so precipitated
4. 4
   ろ過were collected by filtration
5. 5
   その他dried

実験手順

(R)-(−)-2-[3-[3-(1-tert-Butylcarbonylmethyl-2-oxo-5-c yclohexyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-3-yl)urei do]phenyl]-2-methylpropionic acid (158 mg) and N,N′-dibenzylethylenediamine (67 mg) were added to acetonitrile (2 mL), and were then dissolved under heat. The reaction mixture was allowed to stand. Crystals so precipitated were collected by filtration and dried, whereby the title compound (200 mg) was obtained. Yield: 89%.

出典