反応 #1779

反応方程式

methyl 4-(4-chromanoyloxy)-2-methoxybenzoate

H2O

LiOH.H2O

→

4-(4-chromanoyloxy)-2-methoxybenzoic acid

溶媒

THF

反応条件

後処理

1. 1
   温度cooled to ambient temperature
2. 2
   その他The solvent was removed under reduced pressure
3. 3
   洗浄MeOH(NH3) and eluted with same
4. 4
   その他The solvent was removed under reduced pressure

実験手順

To a stirred solution of methyl 4-(4-chromanoyloxy)-2-methoxybenzoate (260 mg, 0.82 mmol) in THF:H2O (4 mL:0.8 mL) was added LiOH.H2O (172 mg, 4.1 mmol). The reaction was heated to 45° C. over 12 h and then cooled to ambient temperature. The solvent was removed under reduced pressure. The crude solid was passed through a small plug of silca gel packed in 90:10 CH2Cl2 :MeOH(NH3) and eluted with same. The solvent was removed under reduced pressure to afford 4-(4-chromanoyloxy)-2-methoxybenzoic acid as a foam.

出典