反応 #1772481

反応方程式

2-nitro-1-(3-methoxyphenyl)ethanol

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product

収率 29.0%

2-amino-1-(3-methoxyphenyl)ethanol

収率 29.0%

溶媒

MeOH

反応条件

後処理

1. 1
   ろ過filtered through Celite
2. 2
   濃縮concentrated
3. 3
   その他purified by flash chromatography (0-100% EtOAc:hexane)

実験手順

A suspension of 2-nitro-1-(3-methoxyphenyl)ethanol (688 mg, 3.49 mmol), PtO2 (160 mg) in MeOH (10 mL) was pressurized to 40 psi H2 and shaken in a Parr shaker overnight. The reaction was depressurized, filtered through Celite, concentrated, purified by flash chromatography (0-100% EtOAc:hexane) to afford 169 mg of the product as an oil: 1H NMR (400 MHz, CDCl3) δ ppm 7.24 (t, J=7.96 Hz, 1H), 6.85-6.93 (m, 2H), 6.80 (m, 1H), 4.60 (dd, J=7.83, 4.04 Hz, 1H), 3.79 (s, 3H), 2.96 (dd, J=12.76, 3.92 Hz, 1H), 2.79 (dd, J=12.76, 7.71 Hz, 1H), 2.19 (s, 3H).

出典