反応 #1772026

反応方程式

(R)-((S)-1-phenylethyl) 2-(2-fluorophenyl)-2-(piperidin-1-yl)acetate

→

title compound

収率 98.1%

(R)-2-(2-fluorophenyl)-2-(piperidin-1-yl)acetic acid

収率 98.1%

溶媒

ethanol

反応条件

後処理

1. 1
   その他was hydrogenated at room temperature
2. 2
   その他The solution was then purged with Ar
3. 3
   ろ過filtered through diatomaceous earth (Celite®)
4. 4
   濃縮concentrated in vacuo

実験手順

A mixture of (R)-((S)-1-phenylethyl) 2-(2-fluorophenyl)-2-(piperidin-1-yl)acetate (0.737 g, 2.16 mmol) and 20% Pd(OH)2/C (0.070 g) in ethanol (30 mL) was hydrogenated at room temperature and atmospheric pressure (H2 balloon) for 2 hours. The solution was then purged with Ar, filtered through diatomaceous earth (Celite®), and concentrated in vacuo. This provided the title compound as a colorless solid (0.503 g, 98%). 1H NMR (400 MHz, CD3OD) δ 7.65 (ddd, J=9.1, 7.6, 1.5 Hz, 1H), 7.47-7.53 (m, 1H), 7.21-7.30 (m, 2H), 3.07-3.13 (m, 4H), 1.84 (br s, 4H), 1.62 (br s, 2H). LCMS: Anal. Calcd. for C13H16FNO2: 237. found: 238 (M+H)+.

出典