反応 #1772001

反応方程式

2,6-dinitrotoluene

N,N-dimethylformamide dimethylacetal

→

dimethylaminostyrene

収率 139.3%

溶媒

DMF

反応条件

後処理

1. 1
   その他The mixture was then evaporated
2. 2
   濃縮to concentrate to a reddish-black oil

実験手順

A mixture solution of 2,6-dinitrotoluene (18.2 g, 0.1 mol) and N,N-dimethylformamide dimethylacetal (28 mL, d=0.89, 0.2 mol) in anhydrous DMF (80 mL) was refluxed for 5 h. The mixture was then evaporated to concentrate to a reddish-black oil. After run flash column using CH2Cl2:MeOH (10:1) as eluent to give a red crystalline solid intermediate, 2,6-dinitro-trans-{circumflex over (α)}-dimethylaminostyrene (20.5 g, yield 86%).

出典