反応 #1771991

反応方程式

Boc-Pro(4,4-diMe)-OH

thionylchloride

methanol

→

4,4-Dimethylproline Methylester Hydrochloride Salt

反応条件

後処理

1. 1
   濃縮The reaction mixture was concentrated to an amorphous solid (377 mg, 95%)

実験手順

To a solution of Boc-Pro(4,4-diMe)-OH (0.5 g, 2.06 mmol) in anhydrous methanol (8 ml) was added dropwise thionylchloride (448 g, 6.18 mmol) and the reaction was stirred for six hours at room temperature. The reaction mixture was concentrated to an amorphous solid (377 mg, 95%).

出典