反応 #1771988

反応方程式

methyliodide

lithium hexamethyldisilazide

tert-butyl N-tert-butoxycarbonyl-4-methyl-L-pyroglutamate

→

Boc-PyroGlu(4,4-dimethyl)-OtBu

収率 54.0%

Tert-butyl N-tert-butoxycarbonyl-4,4-dimethyl-L-pyroglutamate

収率 54.0%

溶媒

tetrahydrofuran

tetrahydrofuran

反応条件

後処理

1. 1
   workup.WAITAfter an additional 3 hours at −78° C.
2. 2
   その他the cooling bath was removed
3. 3
   workup.ADDITION50% saturated aqueous ammonium chloride (40 mL) was added
4. 4
   抽出extracted with ether (2×50 mL)
5. 5
   洗浄The combined organic layers were washed with water(2×25 mL), saturated sodium bicarbonate (2×25 mL), brine (50 mL)
6. 6
   乾燥dried (Na2SO4)
7. 7
   ろ過filtered
8. 8
   濃縮concentrated

実験手順

To a solution of tert-butyl N-tert-butoxycarbonyl-4-methyl-L-pyroglutamate (1.2 g, 4.0 mmol) in tetrahydrofuran (20 mL) stirring at −78° C., was added a 1M solution of lithium hexamethyldisilazide in tetrahydrofuran (4.4 mL, 4.4 mmol) dropwise over 5 minutes. After 30 minutes, methyliodide (0.33 mL, 5.2 mmol) was added. After an additional 3 hours at −78° C., the cooling bath was removed and 50% saturated aqueous ammonium chloride (40 mL) was added. The solution was stirred for 20 minutes, then extracted with ether (2×50 mL). The combined organic layers were washed with water(2×25 mL), saturated sodium bicarbonate (2×25 mL), brine (50 mL), dried (Na2SO4), filtered and concentrated to give Boc-PyroGlu(4,4-dimethyl)-OtBu (0.673 g, 54%).

出典