反応 #1769

反応方程式

methyl 4-hydroxy-2-methoxybenzoate

3,5-dichloro-1-fluoropyridinium triflate

→

methyl 5-fluoro-4-hydroxy-2-methoxybenzoate

溶媒

CH2Cl2

反応条件

後処理

1. 1
   温度The solution was refluxed for 48 h
2. 2
   その他The crude oil was purified by pressurized silica gel column chromatography
3. 3
   その他Evaporation of the CH2Cl2

実験手順

To a stirred solution of the methyl 4-hydroxy-2-methoxybenzoate (1 g, 5 mmol, from Step 3) in CH2Cl2 (20 mL) was added 3,5-dichloro-1-fluoropyridinium triflate (2.25 g, 6 mmol). The solution was refluxed for 48 h and then cooled to ambient temperature and stripped down under reduced pressure. The crude oil was purified by pressurized silica gel column chromatography using 99:1 CH2Cl2 :MeOH. Evaporation of the CH2Cl2 :MeOH mixture gave the desired methyl 5-fluoro-4-hydroxy-2-methoxybenzoate as a white powder.

出典