反応 #1768455

ord-09ed34953e8b46caa1e039bb8206abbd

反応方程式

C[C@H](CCC(=O)NCCS(=O)(=O)[O-])[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C.[Na+]
taurocholic acid
CCCCCCCC/C=C\CCCCCCCC(=O)OCC(O)CO
monoolein
C[C@H](CCC(=O)NCCS(=O)(=O)[O-])[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C.[Na+]
taurocholic acid
CCCCCCCC/C=C\CCCCCCCC(=O)OCC(O)CO
monoolein
CCCCCCCC/C=C\CCCCCCCC(=O)OCC(O)CO
monoolein
C[C@H](CCC(=O)NCCS(=O)(=O)[O-])[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C.[Na+]
taurocholic acid
→
CCCCCCCC/C=C\CCCCCCCC(=O)OCC(O)CO.C[C@H](CCC(=O)NCCS(=O)(=O)[O-])[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C.[Na+]
Monoolein Taurocholic acid

反応物

C[C@H](CCC(=O)NCCS(=O)(=O)[O-])[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C.[Na+]
taurocholic acid
CCCCCCCC/C=C\CCCCCCCC(=O)OCC(O)CO
monoolein
C[C@H](CCC(=O)NCCS(=O)(=O)[O-])[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C.[Na+]
taurocholic acid
CCCCCCCC/C=C\CCCCCCCC(=O)OCC(O)CO
monoolein
CCCCCCCC/C=C\CCCCCCCC(=O)OCC(O)CO
monoolein
C[C@H](CCC(=O)NCCS(=O)(=O)[O-])[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C.[Na+]
taurocholic acid

試薬

なし

溶媒

O
water
O
water

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    温度the volume of the solution was increased to 60 ml
  2. 2
    その他was stored at 10° C.

実験手順

1.35 g of taurocholic acid was dissolved in 15 ml of de-ionized water and the volume of the solution was increased to 60 ml by adding more deionized water. Then, 0.89 mg of monoolein was slowly added to the solution over 20 mins. using an ice bath on a sonic mixer. The final monoolein and taurocholic acid concentration was 20 mM (the molecular weight of taurocholic acid is 537.7 g and that of monoolein is 356.5 g). The mixture was stored at 10° C.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US05169944uspto-grants-1992_12