反応 #1767724

反応方程式

isoeugenol

acetic anhydride

→

Acetyl isoeugenol

収率 62.0%

溶媒

pyridine

反応条件

後処理

1. 1
   workup.STIRRINGAfter stirring for three hours
2. 2
   ろ過the resulting precipitate is filtered
3. 3
   洗浄washed with water (3×500 ml.)
4. 4
   その他dried in vacuo
5. 5
   その他to give 381.7 g

実験手順

To a solution of isoeugenol (344 g., 2.1 moles) in 420 ml. of pyridine under nitrogen atmosphere is added 428 ml. of acetic anhydride over a period of 30 minutes. The resulting solution is stirred at room temperature overnight followed by treatment with ice-water (1400 ml.). After stirring for three hours, the resulting precipitate is filtered, washed with water (3×500 ml.) and dried in vacuo to give 381.7 g. of crude product. Acetyl isoeugenol (269 g., 62%) is obtained from washing the crude product with n-hexane.

出典