反応 #1758

反応方程式

trans-O-(4-chlorophenylacetyl)-4-(4-dimethylaminomethylphenyl)-cyclohexanol

hydrogen chloride

→

trans-O-(4-Chlorophenylacetyl)-4-(4-dimethylaminomethylphenyl)-cyclohexanol-hydrochloride

溶媒

isopropanol

diethyl ether

反応条件

後処理

1. 1
   その他is combined at ambient temperature
2. 2
   workup.ADDITIONadded dropwise
3. 3
   その他The precipitate formed
4. 4
   ろ過suction filtered
5. 5
   洗浄washed repeatedly with diethyl ether
6. 6
   その他dried
7. 7
   その他White crystals are obtained

実験手順

A solution of 0.39 g (0.001 mol) of trans-O-(4-chlorophenylacetyl)-4-(4-dimethylaminomethylphenyl)-cyclohexanol in 10 ml of diethyl ether is combined at ambient temperature, with stirring, with a 1.5 times equimolar amount of hydrogen chloride in isopropanol added dropwise. The precipitate formed is left for 1 hour at ambient temperature, suction filtered, washed repeatedly with diethyl ether and dried. White crystals are obtained, melting point 231°-233° C.

出典