反応 #1755471

反応方程式

N-Boc-4-piperidinemethanol

Toluene sulfonyl chloride

pyridine

→

title compound

4-(Toluene-4-sulfonyloxymethyl)-piperidine-1-carboxylic acid tert-butyl ester

溶媒

chloroform

反応条件

後処理

1. 1
   workup.STIRRINGto stir for 24 hours
2. 2
   その他Standard workup and chromatographic purification

実験手順

A solution of N-Boc-4-piperidinemethanol, 5.0 g (23.2 mmol) in chloroform, 50 mL, was prepared. Toluene sulfonyl chloride, 5.75 g (30.2 mmol), in 5.6 mL of pyridine (69.6 mmol) was added. The solution was stirred under nitrogen allowed to stir for 24 hours. Standard workup and chromatographic purification provided the title compound. Yield 6.0 g

出典