反応 #1755462

反応方程式

2-(3,5-dimethyl-phenyl)-1-thiophen-2-yl-ethylamine

2-(3,5-Dimethyl-phenyl)-1-thien-2-yl-ethylamine

acetic acid 2-isothiocyanato-ethyl ester

→

product

収率 25.7%

Acetic Acid 2-{3-[2-(3,5-dimethyl-phenyl)-1-thien-2-yl-ethyl]-thioureido}-ethyl Ester

収率 25.7%

溶媒

toluene

反応条件

後処理

1. 1
   その他evaporated
2. 2
   その他the residue purified by column chromatography

実験手順

A solution of 2-(3,5-dimethyl-phenyl)-1-thiophen-2-yl-ethylamine (1.4 g, from example 1) and acetic acid 2-isothiocyanato-ethyl ester (0.75 g, prepared according to Collect. Czech. Chem. Commun. 1986, 51, 112-117) in toluene (15 ml) was stirred at room temperature for 12 h, evaporated and the residue purified by column chromatography to yield the product (0.5 g) as a yellowish oil.

出典