反応 #1755461

反応方程式

2-methyl-propane-2-sulfinic acid [2-(3,5-dimethyl-phenyl)-1-(1-methyl-1H-pyrazol-4-yl)-ethyl]-amide

hydrogenchloride

→

2-(3,5-Dimethyl-phenyl)-1-(1-methyl-1H-pyrazol-4-yl)-ethylamine

収率 77.0%

溶媒

methanol

dioxane

反応条件

後処理

1. 1
   その他The reaction mixture was quenched with aqueous potassium carbonate solution
2. 2
   抽出extracted
3. 3
   乾燥the organic phases dried over magnesium sulfate
4. 4
   その他After evaporation of the solvent a yellowish oil
5. 5
   その他was obtained in 77% yield (1.05 g)

実験手順

A solution of RS 2-methyl-propane-2-sulfinic acid [2-(3,5-dimethyl-phenyl)-1-(1-methyl-1H-pyrazol-4-yl)-ethyl]-amide (2.0 g) in methanol (12 ml) was treated with a solution of hydrogenchloride in dioxane (12 ml, 4 N) at room temperature overnight. The reaction mixture was quenched with aqueous potassium carbonate solution and adjusted to pH 8-9, extracted and the organic phases dried over magnesium sulfate. After evaporation of the solvent a yellowish oil was obtained in 77% yield (1.05 g).

出典