反応 #1755456

反応方程式

imidazole

methyl 4-fluorobenzoate

potassium carbonate

→

1-(4′-methoxycarbonylphenyl)imidazole

収率 59.0%

溶媒

DMSO

反応条件

後処理

1. 1
   温度After cooling to room temperature
2. 2
   ろ過Precipitated product is filtered off
3. 3
   洗浄washed with water

実験手順

A mixture of imidazole (132 g, 1.9 mol), methyl 4-fluorobenzoate (170 ml, 1.3 mol) and potassium carbonate (357 g, 2.6 mol) in DMSO (200 ml) is stirred at 120° C. for 3 h. After cooling to room temperature, the mixture is added to ice-water. Precipitated product is filtered off and washed with water. Yield: 59%.

出典