反応 #1747841

反応方程式

triisopropyl borate

hexane

n-butyllithium

hydrochloric acid

1-(3-bromophenyl) naphthalene

→

3-(1-naphthyl)phenylboronic acid

収率 71.9%

溶媒

toluene

THF

反応条件

後処理

1. 1
   workup.STIRRINGThen, the reaction mixture was stirred for two hours at −60 degrees C
2. 2
   温度The reaction solution was further cooled down to −60 degrees C
3. 3
   温度Subsequently, the reaction mixture was warmed up to room temperature
4. 4
   workup.STIRRINGstirred for 17 hours
5. 5
   workup.STIRRINGto be stirred for one hour at room temperature
6. 6
   その他After the reaction
7. 7
   乾燥After organic phase thereof was dried with magnesium sulfate
8. 8
   workup.DISTILLATIONthe solvent was distilled away under reduced pressure
9. 9
   その他By recrystallizing the obtained solid by toluene

実験手順

Under an argon gas atmosphere, a mixture of 200.0 g (706.3 mmol) of 1-(3-bromophenyl) naphthalene and 2.1 L of dehydrated THF was cooled down to −60 degrees C., and added with 543 mL (847 mmol) of hexane solution of 1.56M n-butyllithium in drops while being stirred. Then, the reaction mixture was stirred for two hours at −60 degrees C. The reaction solution was further cooled down to −60 degrees C. and added with 398.5 g (2.119 mol) of triisopropyl borate in drops. Subsequently, the reaction mixture was warmed up to room temperature, and stirred for 17 hours. The reaction mixture was further added with solution of hydrochloric acid to be stirred for one hour at room temperature. After the reaction, the reaction mixture was further added with toluene, so that aqueous phase thereof was eliminated. After organic phase thereof was dried with magnesium sulfate, the solvent was distilled away under reduced pressure. By recrystallizing the obtained solid by toluene, 126 g of 3-(1-naphthyl)phenylboronic acid was obtained at an yield of 67%.

出典