反応 #1736046

反応方程式

N-Bromosuccinimide

2-phenyl-4-penten-1-ol

water

→

2-(bromomethyl)-4-phenyltetrahydrofuran

収率 70.2%

溶媒

chloroform

反応条件

後処理

1. 1
   その他The chloroform layer is separated
2. 2
   乾燥dried over magnesium sulfate
3. 3
   workup.DISTILLATIONthe solvent is distilled off under reduced pressure
4. 4
   その他The residue is purified by column chromatography on silica gel with chloroform eluant

実験手順

N-Bromosuccinimide (1.78 g) is added to a stirred solution of 1.6 g of 2-phenyl-4-penten-1-ol in 15 ml of chloroform at room temperature. The resulting mixture is stirred at room temperature for 3 hours. The reaction mixture is then poured into 10 ml of water. The chloroform layer is separated and dried over magnesium sulfate, and the solvent is distilled off under reduced pressure. The residue is purified by column chromatography on silica gel with chloroform eluant to give 1.67 g of 2-(bromomethyl)-4-phenyltetrahydrofuran as colorless oil.

出典