反応 #1726707

反応方程式

2-(N-Boc-amino)-5-chloro-3-phenyl-thiophene

trifluoroacetic acid

→

2-amino-5-chloro-3-phenylthiophene

溶媒

DMF

dichloromethane

反応条件

後処理

1. 1
   その他the more volatile materials removed under reduced pressure
2. 2
   その他The resulting DMF solution of 2-amino-5-chloro-3-phenylthiophene was used in the subsequent coupling step without purification

実験手順

2-(N-Boc-amino)-5-chloro-3-phenyl-thiophene (66 mg, 0.21 mmol) was treated with trifluoroacetic acid (1 ml) in dichloromethane (3 ml) at ambient temperature for 1 hr. The mixture was diluted with DMF (1 ml) and the more volatile materials removed under reduced pressure. The resulting DMF solution of 2-amino-5-chloro-3-phenylthiophene was used in the subsequent coupling step without purification.

出典