反応 #1726706

反応方程式

2-(N-Boc-amino)-3-phenyl-thiophene

N-chlorosuccinimide

→

2-(N-Boc-amino)-5-chloro-3-phenyl-thiophene

収率 66.6%

溶媒

dichloromethane

dichloromethane

反応条件

後処理

1. 1
   その他at 0° C.
2. 2
   洗浄washed with water
3. 3
   濃縮the organic phase concentrated in vacuo

実験手順

To 2-(N-Boc-amino)-3-phenyl-thiophene (89 mg, 0.32 mmol) in dichloromethane (4 ml) at 0° C. was slowly added N-chlorosuccinimide (48 mg, 0.36 mmol), and the mixture allowed warm to ambient temperature for 16 hr. The mixture was diluted with dichloromethane, washed with water, and the organic phase concentrated in vacuo. Flash chromatography on silica gel (ethyl acetate/hexanes) yielded 2-(N-Boc-amino)-5-chloro-3-phenyl-thiophene (66 mg, 66%).

出典