反応 #1726705

反応方程式

5-amino-1-(3′-nitrophenyl)-4-cyanopyrazole

phosphoric acid

ammonium hydroxide

→

5-amino-1-(3′-nitrophenyl)-pyrazole

収率 80.0%

反応条件

後処理

1. 1
   抽出The organics were extracted three times with diethyl ether (total 40 ml)
2. 2
   洗浄washed with brine
3. 3
   乾燥dried over magnesium sulfate
4. 4
   その他Removal of solvent

実験手順

5-amino-1-(3′-nitrophenyl)-4-cyanopyrazole (559 mg, 2.44 mmol) and phosphoric acid (86%, 6 ml) were refluxed at 170° C. for 15 h. The reaction was cooled to room temperature and neutralized with ammonium hydroxide. The organics were extracted three times with diethyl ether (total 40 ml), washed with brine, and dried over magnesium sulfate. Removal of solvent gave 5-amino-1-(3′-nitrophenyl)-pyrazole as a yellow powder (398 mg, 80% yield).

出典