反応 #1726698

ord-89517c2aef894390b29f68af5590b7b2

反応方程式

CCOC(OCC)OCC
orthoformic acid triethyl ester
Nc1[nH]ncc1-c1ccccc1
4-phenyl-2H-pyrazol-3-ylamine
N#CCc1ccccc1
benzeneacetonitrile
N#CC(C=O)c1ccccc1
3-oxo-2-phenyl-propionitrile

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

4-Aryl-3-aminopyrazoles such as 4-phenyl-2H-pyrazol-3-ylamine may be prepared according to the procedures described in patent EP269,859 and illustrated in scheme 8, by reacting benzeneacetonitrile with orthoformic acid triethyl ester to give 3-oxo-2-phenyl-propionitrile which is reacted with hydrazine.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US08110568B2uspto-grants-2012_02