反応 #1726675

反応方程式

methyl benzoyl formate

(−) cinchonidine

→

(R)-methyl mandelate

収率 87.5%

溶媒

toluene

反応条件

後処理

1. 1
   ろ過filtration
2. 2
   その他after the reaction
3. 3
   濃縮The filtrate was concentrated
4. 4
   その他the residue was purified

実験手順

Five percent Ir/C (38.4 mg, 0.01 mmole), methyl benzoyl formate (164.2 mg, 1.0 mmole), (−) cinchonidine (3.8 mg, 0.013 mmole) and toluene (5 ml) were mixed in an autoclave and were agitated for five hours at room temperature under hydrogen at a pressure of 50 atmospheres. The cross-linked Ir/C cluster composition was removedby filtration after the reaction. The filtrate was concentrated, and the residue was purified using PTLC to obtain (R)-methyl mandelate (145.4 mg, 87.5% yield). The asymmetric yield was 2.0% ee.

出典