反応 #1726671

反応方程式

(−) cinchonidine

hydrogen

methyl benzoyl formate

→

(R)-methyl mandelate

収率 88.5%

溶媒

toluene

反応条件

後処理

1. 1
   workup.ADDITIONwere mixed in an autoclave
2. 2
   その他was removed by filtration
3. 3
   その他after the reaction
4. 4
   濃縮The filtrate was concentrated
5. 5
   その他the residue was purified

実験手順

The cross-linked Ir cluster composition obtained in Example 10 (14.4 mg, 0.01 mmole), methyl benzoyl formate (164.2 mg, 1.0 mmole), (−) cinchonidine (3.8 mg, 0.013 mmole) and toluene (5 ml) were mixed in an autoclave and agitated for five hours at room temperature in a hydrogen atmosphere at 50 atmospheres pressure. The cross linked Ir cluster composition was removed by filtration after the reaction. The filtrate was concentrated, and the residue was purified using PTLC to obtain (R)-methyl mandelate (147.1 mg, 88.5% yield). The asymmetric yield was 47.1% ee.

出典