反応 #172545

反応方程式

2-docosa-4,7,10,13,16,19-hexaenamido-4-methylpentanoic acid

ethyl 2-hydroxybenzoate

DCC

→

ethyl 2-(2-docosa-4,7,10,13,16,19-hexaenamido-4-methylpentanoyloxy)benzoate

収率 67.0%

溶媒

CH3CN THF

反応条件

後処理

1. 1
   ろ過filtered
2. 2
   濃縮concentrated under reduced pressure
3. 3
   その他The crude product was purified by silica gel chromatography (EtOAc-PE, 0-20%)

実験手順

To a solution of 2-docosa-4,7,10,13,16,19-hexaenamido-4-methylpentanoic acid (50 mg, 0.11 mmol) and ethyl 2-hydroxybenzoate (19 mg, 0.11 mmol) in CH3CN/THF (1:1, 0.5 mL) at −10° C. was added DCC (12 mg, 0.11 mmol) and DMAP (1 mg). The mixture was stirred (RT, 16 h), filtered and concentrated under reduced pressure. The crude product was purified by silica gel chromatography (EtOAc-PE, 0-20%) to afford ethyl 2-(2-docosa-4,7,10,13,16,19-hexaenamido-4-methylpentanoyloxy)benzoate (40 mg, 67%) as colorless oil. Mass calculated for C37H51NO5=589.80; found: [M+H]+=590.4.

出典