反応 #172350

反応方程式

2-bromo-5-hydroxybenzaldehyde

4-(2-chloroethyl)morpholine hydrochloride

K2CO3

→

2-bromo-5-(2-morpholinoethoxy)benzaldehyde

収率 72.0%

溶媒

DMF

反応条件

後処理

1. 1
   その他After reaction 2 h at 120° C. for 3 h
2. 2
   その他the reaction mixture was quenched by addition of water
3. 3
   抽出extracted with EtOAc
4. 4
   乾燥The organic layer was dried over Na2SO4
5. 5
   濃縮concentrated under reduced pressure

実験手順

To a mixture of 2-bromo-5-hydroxybenzaldehyde (62; 3 g, 15 mmol) and 4-(2-chloroethyl)morpholine hydrochloride (120; 5.6 g, 30 mmol) in DMF (75 mL) was added K2CO3 (10.3 g, 74.6 mmol). After reaction 2 h at 120° C. for 3 h, the reaction mixture was quenched by addition of water and extracted with EtOAc. The organic layer was dried over Na2SO4 and concentrated under reduced pressure. Column chromatography afforded 2-bromo-5-(2-morpholinoethoxy)benzaldehyde 121 (3.3 g, 72%) as a brown solid.

出典