反応 #1722270

反応方程式

4-Chloro-3-methoxy-2-methyl-pyridine

N-bromo-succinimide

benzoyl peroxide

→

4-Chloro-3-methoxy-2-bromomethyl-pyridine

溶媒

carbon tetrachloride

反応条件

後処理

1. 1
   温度The reaction mixture is refluxed under UV irradiation for 1.5 hour
2. 2
   ろ過The solid is filtered
3. 3
   温度after cooling
4. 4
   その他the solvent evaporated
5. 5
   その他The desired product is purified by chromatography on silica gel

実験手順

4-Chloro-3-methoxy-2-methyl-pyridine (6.12 g) is dissolved in carbon tetrachloride (80 ml) then N-bromo-succinimide (7.12 g) and benzoyl peroxide (1 g) are added. The reaction mixture is refluxed under UV irradiation for 1.5 hour. The solid is filtered after cooling and the solvent evaporated. The desired product is purified by chromatography on silica gel.

出典