反応 #1721763

反応方程式

water

1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride

hydroxybenzotriazole

8-chloro-6,11-dihydro-11-(1-piperazinyl)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine

urocanic acid

→

title compound

1-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-4-[(E)-3-(1H-imidazol-4-yl)-1-oxo-2-propenyl]piperazine

溶媒

N,N-dimethylformamide

反応条件

後処理

1. 1
   workup.DISSOLUTIONdissolved (˜10 min.)
2. 2
   workup.STIRRINGto stir at room temperature for 18.5 h
3. 3
   workup.STIRRINGthe solution was stirred briefly
4. 4
   濃縮before concentrating under reduced pressure
5. 5
   その他The residual oil was partitioned between dichloromethane (100 mL) and water (100 mL)
6. 6
   抽出The organic extract
7. 7
   乾燥was dried by filtration through anhydrous magnesium sulfate and solvent
8. 8
   その他removed under reduced pressure
9. 9
   その他The residue was chromatographed on silica gel
10. 10
    洗浄eluting with dichloromethane-methanol-concentrated ammonium hydroxide (90:9:0.5)

実験手順

To a suspension of urocanic acid (1.38 g; 10.0 mmol) (from Aldrich Chemicals) in N,N-dimethylformamide (175 mL) under an inert atmosphere, was added 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (1.92 g; 10.0 mmol) and hydroxybenzotriazole (1.08 g; 8 mmol). The resultant mixture was warmed to 40° C. and stirring continued until all solids dissolved (˜10 min.). To the resultant solution was added 8-chloro-6,11-dihydro-11-(1-piperazinyl)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine (8) (2.51 g; 8.0 mmol), and the resultant solution was allowed to stir at room temperature for 18.5 h. Then water (250 microliters; 13.9 mmol) was added, and the solution was stirred briefly before concentrating under reduced pressure. The residual oil was partitioned between dichloromethane (100 mL) and water (100 mL). The organic extract was dried by filtration through anhydrous magnesium sulfate and solvent removed under reduced pressure. The residue was chromatographed on silica gel, eluting with dichloromethane-methanol-concentrated ammonium hydroxide (90:9:0.5), to obtain the title compound as a yellow powder that decomposed to a frothy gum at 160° C. SIMS: 434 (MH+; 50%).

出典